Clinical Pharmacist, Pharmaceutical Care Department at King Abdullah International Medical Research, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City –Jeddah, P.O. Box 9515, c/o pharmacy, Jeddah 21423, Saudi Arabia
Dose-independent daptomycin associated rhabdomyolysis: Case report
Author(s): Metwali H* and Elder K
Background: Administration of Daptomycin may be associated with elevation in creatinine phosphokinase (CPK) level and increased risk of rhabdomyolysis with or without acute renal failure with a reported incidence of 2.8% in phase III clinical trials.
Case Presentation: We report the case of 70 years old male patient who had chronic vertebral osteomyelitis based on tissue (bone) culture, lumber spine MRI and abdominal CT. Daptomycin was started at a dose of 6 mg/kg intravenously once daily and continued at home thru Home Health Care (HHC) with baseline CPK=40 IU/L. After six days of treatment, CPK level elevated to 1254 IU/L. Despite initial improvement in CPK with reduction of Daptomycin dose, patient had to be re hospitalized again after 12 days of discharge with CPK level=15825 IU/L and acute kidney injury.
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