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Recommended Conferences

Global Conference on Pharma and Pharmaceutical Sciences

Toronto, Canada

International Conference on Clinical Pharmacy

London, UK

Global Meet on Pharmaceutical Sciences

Zurich, Switzerland
Clinical Pharmacist, Pharmaceutical Care Department at King Abdullah International Medical Research, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City –Jeddah, P.O. Box 9515, c/o pharmacy, Jeddah 21423, Saudi Arabia

Publications

  • Original Article   
    Dose-independent daptomycin associated rhabdomyolysis: Case report
    Author(s): Metwali H* and Elder K

    Abstract

    Background: Administration of Daptomycin may be associated with elevation in creatinine phosphokinase (CPK) level and increased risk of rhabdomyolysis with or without acute renal failure with a reported incidence of 2.8% in phase III clinical trials. Case Presentation: We report the case of 70 years old male patient who had chronic vertebral osteomyelitis based on tissue (bone) culture, lumber spine MRI and abdominal CT. Daptomycin was started at a dose of 6 mg/kg intravenously once daily and continued at home thru Home Health Care (HHC) with baseline CPK=40 IU/L. After six days of treatment, CPK level elevated to 1254 IU/L. Despite initial improvement in CPK with reduction of Daptomycin dose, patient had to be re hospitalized again after 12 days of discharge with CPK level=15825 IU/L and acute kidney injury. .. Read More»