Journal of Basic and Clinical Pharmacy received 13553 citations as per google scholar report
Background: Administration of Daptomycin may be associated with elevation in creatinine phosphokinase (CPK) level and increased risk of rhabdomyolysis with or without acute renal failure with a reported incidence of 2.8% in phase III clinical trials.
Case Presentation: We report the case of 70 years old male patient who had chronic vertebral osteomyelitis based on tissue (bone) culture, lumber spine MRI and abdominal CT. Daptomycin was started at a dose of 6 mg/kg intravenously once daily and continued at home thru Home Health Care (HHC) with baseline CPK=40 IU/L. After six days of treatment, CPK level elevated to 1254 IU/L. Despite initial improvement in CPK with reduction of Daptomycin dose, patient had to be re hospitalized again after 12 days of discharge with CPK level=15825 IU/L and acute kidney injury.
Conclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting Daptomycin treatment and more frequent monitoring in patients with additional risks, including renal impairment, is recommended.
https://betsatgirisi.com https://bettilte.com https://vegabete.com https://kanyongiris.com https://matgiris.com https://celtabetegiris.com https://hilbetegiris.com https://melbete.com https://kinbettinge.com https://wipbett.com https://pusulabetegiris.com https://superbahiss.com https://lidyagiris.com https://holiganbete.com https://1xbetgiriss.com https://asyabahise.com https://jetbahise.com https://betdoksana.com https://betebetle.com https://betgramagiris.com