Dose-independent daptomycin associated rhabdomyolysis: Case report
2 pharmaceutical care department, Internal at King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical, National Guard Health Affeires, Jeddah, Saudi Arabia
Received: 06-Sep-2018 Accepted Date: Sep 26, 2018 ; Published: 28-Sep-2018
Citation: Mettwali H, Elder K. Dose-independent daptomycin associated rhabdomyolysis: Case report. J Basic Clin Pharma October-2018;9(3): 286-288.
This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact reprints@jbclinpharm.org
Abstract
Background: Administration of Daptomycin may be associated with elevation in creatinine phosphokinase (CPK) level and increased risk of rhabdomyolysis with or without acute renal failure with a reported incidence of 2.8% in phase III clinical trials.
Case Presentation: We report the case of 70 years old male patient who had chronic vertebral osteomyelitis based on tissue (bone) culture, lumber spine MRI and abdominal CT. Daptomycin was started at a dose of 6 mg/kg intravenously once daily and continued at home thru Home Health Care (HHC) with baseline CPK=40 IU/L. After six days of treatment, CPK level elevated to 1254 IU/L. Despite initial improvement in CPK with reduction of Daptomycin dose, patient had to be re hospitalized again after 12 days of discharge with CPK level=15825 IU/L and acute kidney injury.
Conclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting Daptomycin treatment and more frequent monitoring in patients with additional risks, including renal impairment, is recommended.
https://betsatgirisi.com https://bettilte.com https://vegabete.com https://kanyongiris.com https://matgiris.com https://celtabetegiris.com https://hilbetegiris.com https://melbete.com https://kinbettinge.com https://wipbett.com https://pusulabetegiris.com https://superbahiss.com https://lidyagiris.com https://holiganbete.com https://1xbetgiriss.com https://asyabahise.com https://jetbahise.com https://betdoksana.com https://betebetle.com https://betgramagiris.com