Background: The Etiological role of Candida albicans in malignant transformation of oral leukoplakia is much debated in the recent times.
Aim and objectives: To compare the clinical and histopathological behavior of oral leukoplakia before and after antifungal therapy with 1% topical clotrimazole. To assess the candida colony count in saliva and correlation between salivary candidal colonies count in patients with oral leukoplakia before and after treatment with antifungal 1% topical clotrimazole therapy.
Methods: Clinical behavior of 50 cases of oral leukoplakia was assessed and histopathological confirmed as not any other lesion. Unstimulated whole saliva sample collection for estimating candida colony count and exfoliative cytology of the lesion were performed with cytobrush to evaluate candidal hyphae and other histopathological changes using PAS and Hematoxylin-Eosin stains. Subjects were prescribed 1% topical clotrimazole thrice daily for two weeks and were recalled after two weeks and the same procedures were repeated sequentially. Paired t test was used for Statistical analysis setting the p value at <0.001.
Results: Statistically significant difference was observed in the clinical staging, histopathological behavior and the salivary candida colony counts before and after treatment with 1% topical clotrimazole. Conclusion: Significant influence of Candida in the Clinico-pathological behavior of leukoplakia merits treatment with topical antifungals like 1%clotrimazole