Google Scholar citation report
Citations : 9722

Journal of Basic and Clinical Pharmacy received 9722 citations as per google scholar report

Indexed In

College of Pharmacy, Guangxi University for Chinese medicine, No.13, Wu He street, Qingxiu District, Nanning ,530200 , Guangxi Province, China


  • Research Article   
    A Novel Nitidine Chloride Nanoparticle Inhibits the Stemness of CD133+EPCAM+ Huh7 Hepatocellular Carcinoma Cells
    Author(s): Danni Li, Qiying Zhang, Yuzhu Zhou, Hua Zhu* and Tong Li*


    Nitidine chloride is a natural product. We synthesized novel nanoparticles of Nitidine chloride (TPGS-FA/NC), which evaluated anti-hepatocellular carcinoma potential capability in vitro and in vivo. Cell viability was assessed by MTT and colony assays; TPGS-FA/NC was examined by Confocal Microscopy though targeting Huh7 Hepatocellular Carcinoma Cells. A sphere culture technique was used to enrich Cancer Stem Cells (CSC) in Huh7 cells. The in vivo antitumor efficacy of TPGS-FA/NC was evaluated in Huh7 cell xenograft model, which were administered by TPGS-FA/NC for 2 weeks. TPGS-FA/NC (10, 20, 40 μg/mL) dose-dependently inhibited the proliferation of HCC cells. Interestingly, TPGS- FA/NC (10, 20, 40 μg/mL) drastically reduced the EpCAM+/CD133+ cell numbers, which suppressed the sphere formation and inhi.. Read More»