Dr, Department of Oncology, Tai Mei Baofa Cancer Hospital, Dongping, Shandong Province, China
Publications
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Research Article
Cancer Immunotherapy Preparation and Immune Cells Activation through Hapten-Enhanced Chemotherapy in Primary Lung Cance
Author(s): Baofa Yu*, Feng Gao, Peng Jing, Peicheng Zhang, Xiaomin Zhang, Guoqin Zheng, Shengjun Zhou, Jian Zhang, Fu Qiang, Yan Han and Yan Jiang
Abstract
Immunotherapy is a novel treatment of lung cancer. However, still lacking of method to awake of immune cell into fighting posture since most of patients got the standard of care with concurrent chemo or radiotherapy. Comparative studies on the single-cell level of immune reaction-related abscopal effect in untreated tumors before and after the major tumor with chemotherapeutic drugs plus hapten. Using Single-cell RNA sequencing (scRNA-seq) analyze the changes at the molecular level of tumor reflection from the treated major tumor. It was found that immunity reaction activated like Mononuclear Phagocytes [MP’s], mature DC cells and T and NK cells including CD8+ effector T cells, CD8Trm, NK cells, also awaking memory T cells, CD8+ effector T cells, CD8Trm and Naive T increased in untreated tumor after major tumor treated. It can be induced through intratumor..
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