Hypersensitivity reaction associated with phenytoin

Author(s): TH Indu, Roopa Satyanarayan Basutkar

Hypersensitivity reactions with antiepileptic drugs (AEDs) are generally associated with aromatic AEDs. We present a case of hypersensitivity reactions followed by administration of phenytoin with diazepam and ranitidine in a patient with generalized tonic‑clonic seizures. Antigen‑antibody reactions or decreased levels of epoxide hydrolase are well known with phenytoin. Increased level of serum phenytoin causing toxicities due to competitive inhibition with diazepam on co‑administration was also reported in the literature. Prevention of the adverse effects with AEDs is a multi‑stage process, which requires implementation of preventive measures through careful monitoring and prompts interventions.

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