Abstract

Hepatoprotective effect of leaves of Peltophorum pterocarpum against paracetamol Induced acute liver damage in rats

The 70% ethanolic extract of Peltophorum pterocarpum leaves were in- vestigated for its hepatoprotective effect against paracetamol induced acute liver dam- age on albino wister rats. Paracetamol (2gm/kg, po) significantly elevated the serum levels of biochemical markers like SGPt, SGOt, ALP, bilirubin (total and direct), total cholesterol, triglycerides and depleted tissue GSH and increased the lipid peroxida- tion. upon administration of paracetamol (2mg/kg p.o.) to albino rats. this indicated that there the 70% ethanolic extract of leaves of Peltophorum pterocarpum at 100mg/kg and 200mg/kg doses significantly reduced the elevated levels of biochemical markers mentioned above. test extract treatment also increased the level of tissue GSH andsignificantly decreased tissue lipid preoxidation. the effect of 70% ethanolic extract (ELPP) was comparable with that of the standard silymarin 100mg/kg. these results suggest that 70% ELPP may have the potential therapeutic value in the treatment of paracetamol induced hepatic damage and some liver diseases. Hepatoprotective activity of the study plant may be attributed to the anti-oxidant principles in it.