Evaluation of Hydrophobic Coated Buoyant Core as Floating Drug Delivery System

Author(s): Maxwell Christopher Manley

An inert hydrophobic buoyant coated core was developed as Floating Drug Delivery System (FDDS) for sustained release of cisapride using direct compression technology. Core contained low density, porous ethyl cellulose, which was coated with an impermeable, insoluble hydrophobic coating polymer such as rosin. It was further seal coated with low viscosity hydroxypropyl methyl cellulose (HPMC E15) to minimize moisture permeation and better adhesion with an outer drug layer. It was found that stable buoyant core was sufficient to float.