Context: Epilepsy is one of the most common chronic neurologic conditions in children, and it is associated with increased risk for poor health-related quality of life. Quality of life is affected by seizure frequency, maternal education, type of epilepsy, and type of anti epileptic in Indian children with epilepsy. Cognition, emotional functions and concentration are most commonly affected due to epilepsy. Aim: The aim of the study was to explore the current status of Quality of Life (QOL) in epileptic children by using QOLCE-55 questionnaire. Materials and Methods: A prospective observational study was carried in our hospital in which 104 children aged 4-13 years with epilepsy were recruited from the inpatient and outpatient services of the department of pediatrics, of a tertiary care teaching hospital in South India. QOLCE questionnaire was completed by parents and epileptic children. The collected data was analyzed by using graph pad prism 7.0 version. Results: The mean overall QOL score was 46.82 ± 10.90. Overall QOL was affected by type of epilepsy, seizure frequency, type of antiepileptic drug and maternal education. Cognitive functions was found to be affected more severely with the lowest mean score of 37.99 ± 18.35, physical functions were not affected much with mean score of 61.10 ± 13.44. We also observed that patients who are receiving Sodium valproate and Iminostilbene like Carbamazepine and Oxcarbamazepine having better QOL than the Phenytoin and Clobazam. Conclusion: Children with epilepsy have a comparatively weaken quality of life and focusing exclusively on control of seizures. In our study we evaluated that most of the patients are having cognitive impairment and decreased social functions. So the patients should be monitored regularly and treated appropriately. We also observed that patients with Sodium valproate and Carbamazepine are having better quality of life.