Background: Asthma is one of the chronic inflammatory disorder of the airways in which many cells and cellular elements play a major role. It is an estimated about 344 million people have the condition as per global asthma network in 2014. The progress of the disease is getting downhill in particular in quickly developing countries, as Ethiopia is one of the east Africa’s fast developing country as evidenced by its GDP improvement. The estimated prevalence of asthma in Ethiopia is about 9.1% as per Global asthma network. So, This study aims to assess the asthma treatment outcomes among the adult patients on follow-up at NEMMH, Southern Ethiopia. Methods: A retrospective study was designed and conducted based on the asthma patient information card at NEMMH for the past two years (Jan 1st 2014-Jan 1st 2016 G.C). The collected data were analyzed by using SPSS software. Results: A total of 174 asthmatic patient’s cards was reviewed, and among the patients majority (62.6%) were male and the mean age of the respondents was 35.1 years with standard deviation (SD) of 9.4. The most (53.45%) used asthma drug combination was Salbutamol with Prednisolone for long term asthma control. Among the patients, 40.8% were prescribed for antibiotics for their respiratory and urinary tract infections. The study found that there is a strong effect of social drug abuse with disease improvement (p-value<0.05). Conclusion: This study has demonstrated that despite the availability of effective therapy for asthma, the control of disease is sub-optimal and it falls short of the standard treatment guidelines set by the global network.