+44-7482878454

Recommended Conferences

Global Conference on Pharma and Pharmaceutical Sciences

Toronto, Canada

International Conference on Clinical Pharmacy

London, UK

Global Meet on Pharmaceutical Sciences

Zurich, Switzerland

Antihistaminic activity of Clitoria ternatea L. roots

Author(s): Dnyaneshwar J Taur, Ravindra Y Patil

Clonidine, a α2 adrenoreceptor agonist induces dose dependent cata-lepsy in mice, which was inhibited by histamine H1 receptor antagonists but not by H2 receptor antagonist. Clonidine releases histamine from mast cells which is respon-sible for different asthmatic conditions. Clitoria ternatea L. (Family: Fabaceae) is a per-imial twing herb. The roots have anti-inflammatory properties and are useful in severe bronchitis, asthma. In present study ethanol extract of Clitoria ternatea root (ECTR) at doses 100, 125 and 150 mg/kg i.p were evaluated for antihistaminic activity using clonidine and haloperidol induced catalepsy in mice. Finding of investigation showed that chlorpheniramine maleate (CPM) and ECTR inhibit clonidine induced catalepsy significantly P < 0.001 when compare to control group, while CPM and ECTR fail to inhibit haloperidol induced catalepsy. Present study concludes that ECTR possesses antihistaminic activity.


Full-Text | PDF