Objectives: The objective of this study was to examine the association of age and racial disparities in addition to obesity, dyslipidemia and diabetes and the burden of prostate cancer. Methods: The National Health and Nutrition Examination Survey (NHANES) data from 2001 to 2010 was used to examine the association between age and racial disparities in addition to obesity (body mass index), lipid and glycemic biomarkers and prostate cancer amongst adults in the United States. Data were analyzed for descriptive statistics and for differences using the t test, Chi-square test and ANOVA. A p value of <0.05 was considered statistically significant. Results: A total of 5,951 adults (40 yrs. and above) were included in this study. Sample mean age was 55.9 years, and 77% were non-Hispanic white. More participants (38%), older than 70 yrs. of age had PSA, total between 4-10 ng/ml and 9% had PSA total greater than 10 ng/ml, which was statistically significant (p<0.05). Similarly, participants younger than 50 yrs. of age had PSA ratio greater than 25% compared to participants older than 60 yrs. of age. These difference in PSA, total and free and PSA ratio was also statistically significant (p<0.05) There was two and half times higher odds of having high PSA, total and 10% odds of having greater than 25% PSA ratio with an increase in age and 20% greater chance of having higher PSA, total and 10% higher odds of having PSA ratio greater than 25%, if you were other than Mexican American such as Non-Hispanic white or black. Conclusions: Age and race/ethnicity found significantly associated with PSA levels. Role and impact of racial disparities and biomarkers discussed above in prostate cancer need further exploration.