Titilope Olubukola Oyebode | Nigeria

Laboratories for Biomembrane Research and Biotechnology, University of Ibadan, Ibadan, Nigeria

Publications

Original Article
Effects of Vacuum Liquid Chromatography (Chloroform) Fraction of the Stem Bark of Alstonia boonei on Mitochondrial Membrane Permeability Transition Pore
Author(s): Oludele John Olanlokun*, Titilope Olubukola Oyebode and Olufunso Olabode Olorunsogo

Abstract
Background: The Mitochondrial Membrane Permeability Transition (MMPT) pore is an important target for the development of cytotoxic drugs because the release of cytochrome c and the irreversible opening of the pore is a point of no return for apoptosis to take place. A. boonei is a perennial plant that is quite ubiquitous in rain forest and sub-Saharan regions and it is used in folklore medicine as an anti-malarial decoction. Objective: To assess the effects of Vacuum Liquid Chromatography (VLC) chloroform (100%) fraction purified from the stem bark extract of A. boonei on MMPT pore of mitochondria isolated from livers of male rats in the presence and absence of added calcium ions. Materials and Methods: The in vitro effects of the VLC chloroform fraction on MMPT were assessed by monitoring the amplitude sw.. Read More»
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