Department of Pharmacotherapeutics, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, Japan
Publications
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Mini Review
The Role of Bone Morphogenetic Protein Signaling in Functioning and Adult Neurogenesis of the Hippocampus
Author(s): Masayoshi Mori* and Yusuke Murata
Abstract
Depression and anxiety are widely prevalent disabling psychiatric disorders. Stressful experiences can contribute to the development and pathogenesis of these disorders. However, current antidepressants still show a delayed onset of action and lack of efficacy. Hence, a deeper understanding of the molecular and cellular mechanisms involved in the pathophysiology of these disorders, as well as the action of antidepressants, may provide further insight into the development of novel fast-acting and more effective therapies. The sub granular zone of the hippocampal dentate gyrus is one of the regions where adult neurogenesis occurs in mammals, including humans, and is well known for its involvement in emotion and stress responses. Adult hippocampal neurogenesis decreases due to stress and increases by the chronic usage of antidepressants, the change in adult hippocampal neurogenesis is in..
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DOI:
10.37532/0976- 0113.13(5).192.
