Department of Neurosurgery, University Hospital LMU Munich, 81377 Munich, Germany
Interstitial PDT on Malignant Gliomas: About the Possible Relation between Optical Spectral Online Monitoring and T1 Hyper intensity in MRI
Author(s): Maximilian Aumiller*, Stefanie Quach, Adrian Ruumlhm and Ronald Sroka
Interstitial Photodynamic Therapy (iPDT) for malignant gliomas using 5-ALA and cylindrical light-diffusing fiber applicators is currently under development. In a preceding investigation, the effects of 5-ALA iPDT on haemoglobin-related light absorption in a liquid phantom model with intact erythrocytes and protoporphyrin IX were experimentally assessed. Spectral monitoring identified a light-induced formation of deoxygenated haemoglobin and methaemoglobin after the onset of iPDT irradiation.
This study summarises the retrospectively analysed spectral data acquired during clinical iPDT interventions of malignant gliomas. The results were analysed for correlations with early postoperative T1-weighted MRI data obtained without a contrast agent. Intrinsic T1-hyperintensity signals were observed and found to be associated with the treatment volume in all patients. This may indica.. Read More»