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Citations : 14978

Journal of Basic and Clinical Pharmacy received 14978 citations as per google scholar report

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Therapeutic monitoring of amikacin and gentamicin in critically and noncritically ill patients

Author(s): Tijana Kovacevic, Sanja Avram, Dragana Milakovic, Nikolina Spiric, Pedja Kovacevic

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of matureâÂ�?�?Â�?�?appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20–30 × 109/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1âÂ�?�?Â�?�?year and cyclic rise up to 50 × 109/L can occur in untreated patients while in others the count may remain stable for years. Based on the cytogenetic and molecular studies, it has been demonstrated that multiple clones may occur in CLL and clonal evolution is a frequent occurrence. The transformation of CLL to a highâÂ�?�?Â�?�?grade nonâÂ�?�?Â�?�?Hodgkin’s lymphoma such as diffuse large B cell lymphoma, Hodgkin lymphoma, and prolymphocytic leukemia is well documented. Whereas the transformation of CLL to acute leukemia occurs in <1% cases and this contrasts the almost invariable progression in patients with chronic myeloid leukemia. Here, we report a rare case of a 55âÂ�?�?Â�?�?yearâÂ�?�?Â�?�?old lady, a diagnosed case of CLL transforming into BâÂ�?�?Â�?�?cell acute lymphocytic leukemia over a very short interval of 1 week period.

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