Susceptibility of Clinical Isolates to Ceftriaxone-Sulbactam at the Ghana Police Hospital

Author(s): Daniel Kwame Afriyie*, Martha Gyansa-Lutterodt, George Asare, Rafik Mahama, Ohene-Mensah Prince and Manu Ofei

Background: Ceftriaxone is the most common and widely used third generation cephalosporin empirically. Extensive use of ceftriaxone makes its highly prone to misutilization with increasing reports of microbial resistance globally, which sometimes linked to production of beta-lactamase. Combination therapy of ceftriaxone with sulbactam, a beta-lactamase inhibitor preserves its antibacterial activity. Periodic local antimicrobial surveillance of antibiotics is necessary to enhance their rational prescribing. Aim: The study aimed at determining susceptibility pattern of clinical isolates from various specimens to ceftriaxonesulbactam at the Ghana Police Hospital. Materials and Methods: Various types of clinical specimen (n=163) from patients were collected from October 2015 to February 2016. Microorganisms were identified after initial culturing at 37°C for 24 hours. Susceptibility of isolated pathogens to ceftriaxone-sulbactam at a break point of 30/15 μg was done using Kirby-Bauer disc diffusion method. Descriptive statistics was used to analyse data. Results: Most prevalent isolates were Coliforms (29.4%), Staphylococcus aureus (27%) and E. coli (17.2%). Overall susceptibility of isolates from the various specimens was 96.4%. Isolates obtained from urine, urethra, sputum and wound specimens showed overall susceptibility rates of 95.7%, 95.2%, 90% and 90% respectively, whilst isolates from the remaining specimens showed 100%. Conclusion: Study revealed high microbial susceptibility to ceftriaxone-sulbactam. Thus, this combination therapy offers a cost-effective alternative in the management of infections which ceftriaxone is recommended


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