Mucormycosis is an opportunistic fungal infection caused by common pathogen of Class Zygomycetes including Mucor, Rhizopus and Absidea species. It is an uncommon disease but is associated with high mortality in immunocompromised host, as in uncontrolled diabetes, and patients with solid and hematologic malignancies, septicemia, and renal disease or on long term treatment with steroids and immunosuppressant. Systemic Mucormycosis usually involves nasopharynx, lungs, gastrointestinal tract and rarely even pericardium. Gastrointestinal Mucormycosis is rare and causes considerable morbidity and mortality due to non-specific presentation often resulting in delayed diagnosis and treatment. We report a case of successive treatment of gastrointestinal angio- invasive Mucormycosis in an adult with acute leukemia during hematopoietic stem cell transplant who recovered with surgical debridement and appropriate intravenous antifungal therapy.