+44-7482878454

Recommended Conferences

Global Meet on Pharmaceutical Sciences

Zurich, Switzerland

Study of Medication Prescribed and Appropriateness of Antimicrobials in Hospitalized Respiratory Tract Infectious Children in Tertiary Care Teaching Hospital, Western Nepal

Author(s): Sudarshan Raj Dhakal*, Bijay Kafle, Bishal Udas, Pabitra Duwadi, Rinky Palikhe, Ram Poudel, Kadir Alam and Gulam Muhammad Khan

Background: Respiratory Tract Infection (RTI) is the global cause of death in children. Nepal, India, Indonesia and Bangladesh account 40% of the global cause. Antimicrobials are the most commonly prescribed drugs in hospitals whose appropriateness solely relies on its rational use. Methods: A cross-sectional study was carried out in pediatric in-patients suffering from the respiratory infection at a tertiary care teaching hospital. WHO/INRUD prescribing indicators and appropriateness index were used in determination of the drug prescribing indicators and appropriateness of antimicrobials. Results: A total of 108 samples male incidence were higher than female. The maximum samples were found in between the age group 1-5 years. Brahaman and Chhetri were the found in larger frequency. Bronchopneumonia 67 and Acute Bronchiolitis 21 (19.4%) were the most common diagnosis. Cefotaxime was the drug found to be used in maximum number 81 (54.4%) following Gentamicin and Amoxy-Clav. In 58 (53.7%) sample Cephalosporin were used as single drug, following its combination with aminoglycosides 20 (18.6%) Out of which cefotaxime and gentamicin combination was found to be in 15 samples. In discharged medication 70.3% of the samples were prescribed with Cephalosporin. The average no of drug per prescription were found to be 4.31. 7.7% of the drugs were found to be prescribed in generic name. The antibiotic encounter per samples and medication from essential drug list were found to be 100%. Conclusion: Total of 140 antibiotics were assessed for appropriateness where 50 (35.71%) of antibiotics were found to be appropriate and 90 (64.29%) were found to be inappropriate. The average Medication Inappropriateness (MAI) was 3.29. The mean MAI per prescription was found to be 1.69 ± 0.47. 33 (31.43%) of the samples were found to be appropriate and 72 (68.57%) sample were found to be inappropriate.


Full-Text | PDF