Self-Medication practice is known as using multiple Over-The-Counter (OTC) drugs to treat your symptoms without physician aid, it is continuously increasing due to unawareness of health care system. Most OTC drugs are usually categorized into pain relievers, cough remedies, anti-allergens, laxatives, vitamins, antacids etc. This study was a community-based, cross-sectional survey carried out in some rural and urban area of Shimla Hills, Himachal Pradesh. To explore self-medication behavior among the general population, a direct interviews with respondents using a previously prepared questionnaire was done. In this study 300 (both male and female) respondents were investigated with age band of 20-60 years, study revealed that males were more prone towards self-medication practice than females. Fever, common cough and cold were the major class of disease associated with this practice. The main reasons for practicing self-medication was simple disease, previous experience with the same condition and considering the current condition uncomplicated with no need to consult a physician.