+44-7482878454

Recommended Conferences

Global Conference on Pharma and Pharmaceutical Sciences

Toronto, Canada

International Conference on Clinical Pharmacy

London, UK

Global Meet on Pharmaceutical Sciences

Zurich, Switzerland

How much Immunogenic are the Oral Polio Vaccines Sourced from the Central Cold-chain Facilities in South-Eastern Nigeria?

Author(s): Angus Nnamdi Oli

Context: There is need for continuous monitoring and validation of pharmaceutical products (including vaccines) in circulation in every country. Vaccines must be maintained in cold-chain from the manufacturer to the end user. Aims: This study aims to validate the Oral Polio vaccines sourced from the Central Coldchain facilities and used for vaccination programmes in South-East, Nigeria. Settings and Design: The Study was an experimental in design and performed in laboratory. Methods and Materials: The immunogenicity test was done using Antibody Induction Method. This involved measuring the neutralizing antibodies in a control group (mice given Oral Polio vaccines stored at 37°C for 12 months) and test group (mice given Oral Polio vaccines sourced from South-east States) after 30 days using Enzyme-Linked-Immunosorbent-Assay technique. Statistical analysis used: One-Way Analysis of Variance (ANOVA), Dunnett’s Tests of Multiple Comparison and Bartlett’s test for equal variances were used. Results: All the vaccines used were within their shelf-life. The Mean ± Standard Deviation of the temperature of the vaccines at point of collection was -19.60 ± 0.56, before storage it was -13.00 ± 3.74 and at storage facility, it was -19.80 ± 0.60. The mean antibody titres evoked by the Oral Polio vaccines from Enugu, Ebonyi, Imo, Anambra, Abia and then the control were 22.90, 23.18, 18.55, 17.12, 17.38 and 7.36 IU/mL respectively. One way analysis of variance shows that there is statistical difference (P value=0.0026) in the antibodies titres produced by the vaccine samples. The antibodies were enough to confer protection against the target diseases. Conclusions: This study showed that the oral polio vaccines from the central cold-chain facilities in south-eastern Nigeria were still in good condition as at the time of sample collection and were immunogenic enough to induce protection. The cost of immunizing a child is heightened by the inbuilt cost of maintaining alternative power supplies to the national power grid. It is, therefore, recommended that vaccines not requiring cold-chain storage is urgently needed in resource-limited countries to reduce the high immunization cost brought about by cold-chain maintenance system. This will strengthen and enhance the process of achieving and sustaining the eradication of infectious diseases, especially polio, in developing countries.
Full-Text | PDF