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Chronic Myeloid Leukemia With Intense Thrombocytosis: A Case Report.

Author(s): K. Laksmi Surekha1*, P. Pavan Kumar2, Ganesh Kumar3

Chronic myeloid leukemia is a hematological malignancies arising
from reciprocal t (9,2), (q34; q11.2) BCR/ABL1 gene in wild primitive
hematopoietic stem cells. Myeloid cells predominate at all series
of maturation, and there may be an Elevated in Thrombocyte count
(ET) and erythroid and megakaryocytic cells at shows peripheral
blood smear; leukocytosis is the main clinical finding, though [1,2].
An elevated in myeloid precursor stem cells, neutrophils, basophils
count, and eosinophils count is present at a peripheral blood smear
and presence of underlying Philadelphia chromosome as a cytogenetic
aberration or BCR-ABL gene transcript as a molecular chromosomal
aberration. A few CML patients can have mild to moderate elevated
platelets count with an acquired JAK2V617F point mutation in about
50% of cases [3]. CML may be two phases a biphasic or triphasic
phase. This phase further classified toward the initial- chronic phase
and a terminal blastic phase, which is preceded by an accelerated
phase in 60% to 80% of cases [4]. In these particular groups of cases
chromosome and thrombocythemia mostly present shows women [5].
This case study presents clinical findings hematological parameters and
molecular genetic analysis data from this case of CML [6].