Angioedema is a rare adverse reaction of carbamazepine, which causes localized tissue edema in submucosal and subcutaneous tissue mediated by histamine, serotonin, and kinins (bradykinin). We report a case of 34âyearâold female who developed angioedema, 24 h after administration of carbamazepine for treating bipolar disorder. Patient’s symptoms responded rapidly with antihistamine therapy and with the withdrawal of carbamazepine, the offending drug. Carbamazepineâinduced angioedema is a lifeâthreatening reaction which requires immediate treatment and monitoring in order to avoid morbidity and mortality.
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