Appropriateness of Ceftriaxone Prescription: A Case of Haramaya Hospital Eastern Ethiopia

Author(s): Debisa Taressa, Teshome Sosengo, Abera Jambo, Eyassu Mathewos, Jemal Abdella, Frehiwot Amare

Background: The irrational use of antibiotics lead to a significant treatment failure, toxicity, drug-drug interaction and increased cost of treatment. Therefore, special attention should be given to antibiotics not only during their development and production, but also during the whole course of time of selection, administration and utilization in the health care system.

Objective: The aim of the study is to assess appropriateness of ceftriaxone prescription at Haramaya Hospital, East Hararghe and Eastern Ethiopia from March 20, 2018 to April 20, 2018 GC.

Methodology: Hospital based retrospective cross sectional study was conducted on 215 Patient’s Medical Record Cards (PMRCs) who received ceftriaxone from January 2018 to December 2019 at Haramaya Hospital, Eastern Ethiopia. Simple random sampling technique was used to select medical record cards. The appropriateness of the ceftriaxone usage was evaluated by using world health organization treatment guideline. Data was analyzed using statistical package software SPPS version 20 and presented in tables and figures.

Results: From the total of 215 patient medical history records reviewed, the 86.8% were in line with the standard treatment guideline of world health organization. Pneumonia (61.9%), urinary tract infection (19.6%), congestive heart failure(4.5%) and surgical cite prophylaxis(4.5%) were the most common disease states for which Ceftriaxone injection was used in Haramaya Hospital. In current study, the 87% of Ceftriaxone prescription was used for appropriate indication. The 13% of Ceftriaxone prescription was for inappropriate indication. Incorrect duration (65.6%) and incorrect indication (13%) were the most common drug therapy problems associated with Ceftriaxone prescription.

Conclusion: In the current study the most common disease state for which Ceftriaxone injection used was for treatment of Pneumonia and urinary tract infection. The dose of 1 gm of Ceftriaxone injection was prescribed in majority of the cases. In significant proportion of the cases, Ceftriaxone injection was prescribed for incorrect indication. In the majority of the cases Ceftriaxone injection was used for empiric treatment followed by for kinetic purpose.


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