Journal of Basic and Clinical Pharmacy received 9722 citations as per google scholar report
The numbers of adults with diabetes in the world is estimated to rise 300 millions in the year 2025 and this leads to increasing search for better anti-diabetic drug. The effects of the ethanol extract (1.25 g/kg) and fractions (Ethyl acetate, dichlo-romethane and butanol in the dose of 1 g/kg) of Anacardium occidentale stem bark on the blood glucose levels in streptozotocin-induced types 1 and 2 diabetic rats at different prandial states were studied. The ethanol extract of A. occidentale had no hypoglycemic effect in type 1 diabetic rats in fasting and postprandial glucose load conditions and, in type 2 diabetic rats in fasting condition. However, the extract, sig-nificantly lowered blood glucose levels in type 2 diabetic rats when fed simultane-ously with glucose. The ethyl acetate fraction showed a significant opposing effect in serum glucose rise after administration of glucose. Additionally, its dichloromethane extract also exhibited a significant reduction in serum glucose level compared to con-trol after glucose administration while its butanol fraction was devoid of this activity. These findings conclude that the active principles responsible for the antihyperglycae-mic effect might be concentrated in the ethyl acetate and dichloromethane fractions of the extract.