Objectives: The present study was undertaken to measure efficacy and tolerability of antiepileptic drugs in patients of epilepsy with a particular reference to the impact on quality of life (QOL). Methods: Adult patients of either gender, diagnosed with epilepsy who reported to the neuromedicine were enrolled after taking permission from Institutional Ethics Committee and were followed up for 6 months. The efficacy of the drug therapy was calculated by counting the number of seizure per month using seizure diary. QOL was measured using Quality of Life in Epilepsy-31-P questionnaire (QOLIE-31-p). Details of suspected adverse drug reactions, if any, were recorded. Statistical evaluation was done with unpaired t test, ANOVA and Pearson Parametric Correlation test. Results: Out of 120 patients, who completed the study 84 were already on drug therapy (OLD group), while 36 were started on drug therapy (NEW group). Sodium valproate was the most common drug prescribed as monotherapy as well as polytherapy. Drug therapy was significantly effective (p<0.001) in NEW group as mean number of seizures decreased from 1.69 ± 0.02/month to 0.25 ± 0.10 at end of six month. In QOL score increased from 50.16 to 70.21 in NEW group and 72.61 to 74.61 in OLD group. Pearson correlation (r) between QOL and efficacy for NEW group showed that QOL improved with decrease in mean number of seizure(r=-0.36). Conclusion Antiepileptic drugs are efficacious in treating and improving the quality of life of patients suffering from epilepsy.