1945 Clinical Implications of Molecular PEGylation on Therapeutic Proteins
A Publication of Global Scientific Forum
Card image

Reviews

Clinical Implications of Molecular PEGylation on Therapeutic Proteins
Authors: Nandhakumar Sathyamoorthy and Dr. Dhanaraju Dasaratha Magharla

Molecular PEGylation has redefined the clinical importance of many biomolecules by improving their pharmacodynamic and pharmacokinetic properties. From its inception, PEGylation has grown substantively into a well-established technology to facilitate the clinical translation of macromolecules by overcoming their limitations. PEGylation renders a number of benefits to therapeutic proteins, such as, increase in hydrodynamic size, extension of circulation half-life, prevention of proteolytic degradation and reduction of immunogenicity and antigenicity. The successful entrance of the PEGylated protein pharmaceuticals to the market, can be ascribed to the unique properties of poly (ethylene glycol) (PEG) conjugated to these proteins. This article aims to review the precise role of PEG in improving the therapeutic efficacy of PEG-protein conjugates approved by regulatory bodies. The data presented herein were extracted from articles published in peer reviewed journals, official websites of manufacturers and safety labeling and drug approval summary of the FDA Centre for Drug evaluation and Research (CDER).

PDF FULL TEXT
Share Now :
journal-of-basic-and-clinical-pharmacy Journal of Basic and Clinical Pharmacy, a publication of Global Scientific Research Forum, is a peer-reviewed online journal with Quarterly print on demand compilation of issues published.
Submit your Manuscript

© Journal of Basic and Clinical Pharmacy
Online since 10 September, 2012 -