Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Egypt
Publications
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Original Article
Hepatoprotective Effects of Hydromethanolic Leaf and Stem
Extracts of Spondias mombin in Carbon Tetrachloride Induced-
Hepatotoxicity and Oxidative Stress
Author(s): Lucky L Nwidu*, Ekramy Elmorsy, Oboma I Yibala and Wayne G Carter
Abstract
Background: Spondias mombin L. (Anacardiaceae) is used in folk medicine in Nigeria for the treatment of hepatitis. Objective: This study comparatively evaluates the in vivo hepatotoprotective and antioxidant effects of Spondias mombin leaf (SML) and stem (SMS) methanolic extracts in rat’s model of hepatotoxicity. Materials and Methods: Acute hepatotoxicity was induced by administering CCl4 to forty-two Wistar rats divided into seven groups. After 48 hours rats were sacrificed and assayed for histological and biochemical indices of hepatotoxicity. Results: Treatment with CCL4 induced hepatocellular injury with significant (p<0.001) increase in the activities of ALT, AST, total bilirubin (TBIL) and conjugated bilirubin (CBIL) and a significant (p<0.001) decrease in total protein (TP) compared to the negative control. The plant extracts, SML 500 and 1000 mg/kg, significantly ..
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