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Director of Transplant Research, Transplant Research Institute, St. Vincent Medical Center, Los Angeles, CA, USA


  • Reviews   
    Vitamin D Receptor (VDR) Gene Polymorphism: Implications on Non-Bone Diseases
    Author(s): Prashant Sakharkar*, Subrata Deb and Don Vu


    Vitamin D, which is also known as “sunshine vitamin”, plays a pivotal role in both bones as well as non-bone organs. The ubiquitous expression of VDR in numerous tissues, including the kidney, heart, muscle, breast, colon, prostate, brain and immune cells, makes this as a natural target of modulation in disease pathogenesis including variety of cancers, metabolic syndrome, renal transplant and dermal disorders. Low vitamin D levels have become an epidemic across the continent irrespective of amount of sunshine during different seasons. The epidemiological studies estimate that currently at least 1 billion people suffer from low vitamin D levels. Vitamin D receptors regulate a number of signaling pathways. These pathways are often involved in inflammation and tumor growth and especially in the epithelial cells of the skin, breast, prostate and colon in case of cancer. Vitam.. Read More»