Why Drug Repurposing (or Drug Repositioning) Fails to Live up to the Promise of Cost-Effective and Time-Effective New Drug Approvals?

Author(s): Glenn C. Begley*

Drug Repurposing is often cited as an efficient and effective way to achieve approval of new therapeutics. There are however, many challenges with this approach. The content of this Mini Review is a summary of a recent publication entitled Drug Repurposing: Misconceptions, Challenges and Opportunities Facing Academic Researchers.

This Mini Review attempts to highlight some of the key issues that are frequently ignored or overlooked, which explains why many drugs that are proposed for repurposing fail to achieve the ultimate goal of a new regulatory label, or a data set that is sufficiently compelling to justify a drug’s use in a new indication.


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