Background: Antibiotic resistance is said to be direct consequence of antibiotic use. Inappropriate prescribing and use practices are putting patients at unnecessary risk for acquisition and spread of resistant and difficult-to-treat pathogens. Methods: A total of 600 prescriptions from various O.P.Ds and 400 case record sheets of the in-patients, 100 each from the department of Medicine, Pediatrics, Obstetrics and Gynecology and Surgery were collected. The data was analyzed as per WHO outpatient prescribing indicators and appropriate prescribing indicators for inpatient antibiotic use. Results: OPD based prescriptions contained 1574 medicines with an average of 2.63 medicines per prescription. Total of 218 antibiotics were prescribed, 3 (1.4%) antibiotics were prescribed as injections. On the whole β-lactams (38.5%) were the most commonly prescribed group. Inpatients case records contained 2958 medicines. Total 606 antibiotics were prescribed for 297 (74%) inpatients that received an average of 2.04 antibiotics. β-lactam was the most commonly prescribed group of antibiotics in the inpatient department. Conclusion: Preparation and implementation of Standard treatment guidelines, antibiotic prescribing policy, prescribing from essential medicine list can make prescribing more rational, safe and help reducing cost of therapy.